Acute Myelogenous Leukemia by Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD

By Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD (eds.)

Acute Myelogenous Leukemia is a well timed compilation of latest innovations within the molecular pathogenesis and molecular treatment of acute myelogenous leukemia (AML). the focal point is on chosen serious molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those components via varied healing brokers and modalities. Bringing jointly new techniques and findings within the uncomplicated and medical technology of AML, the e-book emphasizes the molecular foundation for brand new cures that stand to have the best capability impression at the medical face of those ailments. The textual content offers insights into chosen novel thoughts at the moment and prospectively being constructed, together with interruption of particular sign transduction pathways, modulation of gene expression, makes an attempt to reinstate differentiation, and immunomodulation. there's an emphasis all through at the bidirectional move of data among the scientific and laboratory arenas, and either easy and scientific scientists will take advantage of this translational textual content.

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103. 104. 105. 106. 107. 108. 109. 110. 111. 19 20 PartI I Ravandi and Giles 112. Cortes J, Giles F, O'Brien S, et al. Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders. Cancer 2003;97:2760-2766. 113. Kindler T, Breitenbuecher F, Marx A. Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood 2004;103(10):3644-3654. 114. Tse KF, Mukherjee G, Small D.

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Frank DA. STAT signaling in the pathogenesis and treatment of cancer. Mol Med 1999;5:432-456. scm 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. 19 20 PartI I Ravandi and Giles 112. Cortes J, Giles F, O'Brien S, et al. Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders. Cancer 2003;97:2760-2766. 113. Kindler T, Breitenbuecher F, Marx A. Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia.

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