Biomaterials in Hand Surgery by P. Tranquilli Leali, A. Merolli (auth.), Antonio Merolli,

By P. Tranquilli Leali, A. Merolli (auth.), Antonio Merolli, Thomas J. Joyce (eds.)

This concise yet accomplished booklet is the 1st book dedicated to the functions of biomaterials in hand surgical procedure. It provides simple wisdom within the box of biomaterials, tissue engineering, regenerative drugs, implant layout, and hand joint prostheses, and explores extensive the major subject of metacarpophalangeal joint prostheses in rheumatoid sufferers. additionally, the amount experiences the examine traits for flexor tendon fix and offers new difficult principles for regeneration of peripheral nerves by way of man made nerve publications. the most goal of this paintings is to supply details in one devoted e-book that may hence characterize a short and up-to-date reference for orthopedic surgeons, hand and plastic surgeons, rheumatologists, and fabrics scientists, in addition to mechanical engineers and citizens in those fields.

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2 Potential Applications of Tissue Engineering in Hand Surgery • • 17 formation of large pores (maximum diameter 100 μm) electrospinning: this is a technique where a polymer solution or a molten polymer is drawn from a nozzle by gravity or mechanical pressure and in combination with an electric field, to form non-woven nanofiber matrices. During the process, the electric charge overcomes the surface tension of the polymer solution, transforming the polymer solution droplet into a polymer jet forming solid nanofibers upon solvent evaporation.

Their mechanical behavior is the same irrespective of the direction in which they are loaded. This simplifying hypothesis is never true in a strict sense; nevertheless, for many materials it is acceptable, taking into account the considerable simplification introduced. In the specific case, we can say that the metal of the prosthesis and the bone cement can be thought of as isotropic without committing a significant error. On the other hand, bone, together with almost every natural tissue, is usually strongly anisotropic, its properties varying greatly depending on the loading direction, as a consequence of adaptation and optimization of natural tissues.

However, collagens also play an important role in regulating cell activity and, as a consequence, tissue repair. For example, type I collagen has been shown to promote angiogenesis both in vitro and in vivo [30]. This angiogenic potential has been ascribed to the ability of this protein to control endothelial cell behavior by promoting ligation and, possibly, clustering of the cells. It is known that this control is exerted through binding of plasmalemma α1β1/α2β1 integrin receptors to the amino acid 22 M.

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