Cancer Metastasis -- Related Genes (CANCER METASTASIS -- by D.R. Welch
By D.R. Welch
This quantity is the 1st try and summarize present wisdom in regards to the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. whereas all earlier authors tried to place their findings right into a context for translation to the scientific scenario, the cutting-edge doesn't totally enable this as the box of metastasis is comparatively new. still, the contents of this quantity may be of use to participants of the melanoma learn group and clinicians drawn to constructing and enforcing novel kinds of therapy for melanoma.
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Additional resources for Cancer Metastasis -- Related Genes (CANCER METASTASIS -- BIOLOGY AND TREATMENT Volume 3) (Cancer Metastasis - Biology and Treatment)
Adv Cancer Res 2000; 79:91-121. 40. Yang M, Jiang P, Sun FX, et al. A fluorescent orthotopic bone metastasis model of human prostate cancer. Cancer Res 1999; 59:781-6. 41. Chambers AF, MacDonald IC, Schmidt EE, et al. Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Rev 1995; 14:279-301. 42. MacDonald IC, Schmidt EE, Morris VL, Groom AC, Chambers AF. In vivo videomicroscopy of experimental hematogenous metastasis: cancer cell arrest, extravasation and migration.
Although this comment was made in regard to normal biologic processes, it is equally applicable to the multiple genetic changes that are required for the acquisition of metastatic ability. Metastasis is a complex, multigenic phenotype. As such, multiple markers will be needed for the accurate assessment of the metastatic ability of tumors and tumor cells. This need is highlighted by the tremendous impact of seemingly trivial experimental manipulations on the outcome of metastasis assays (155).
New technologies will continue to increase our ability to dissect molecular pathways in individual cells within human cancers. While this wealth of information will no doubt be of use, work from the groups of Bissell, Cunha, and Chung has clearly demonstrated that tissue structure determines, or at least greatly influences, gene expression and function (147-154). Thus, it may be extremely difficult to predict the importance of genes expressed in individual microdissected cancer cells to the biology of the intact tumor, the behavior of which is determined by complex interactions among a population of cells.