Cell Polarity and Subcellular RNA Localization by Oswald Steward, Paul Worley (auth.), Professor Dr. Dietmar

By Oswald Steward, Paul Worley (auth.), Professor Dr. Dietmar Richter (eds.)

Selective cytoplasmic organelle and protein concentrating on has lengthy been proposal to represent the only real determinant of cellphone polarity and complexity. This view has been replaced, besides the fact that, through the invention of differential subcellular RNA distribution styles. during the last decade it has develop into transparent that selective mRNA sorting and translation contributes to an accumulation of cognate proteins at discrete mobile websites. during this ebook, quite a few platforms are mentioned (e.g. Xenopus oocytes, mammalian mind, invertebrate anxious process) when it comes to RNA trafficking, RNA-targeting sequences (cis-elements) and RNA-transporting proteins (trans-factors), activity-dependent translational legislation and the importance of the cytoskeleton for neuronal functionality and plasticity. It additionally discusses nucleocytoplasmic export of mRNA and viral RNA as one other instance of subcellular RNA kinesis.

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A prominent characteristic of event-memory is, however, that some events are remembered for a long time, and others only for a short time. In fact, the human capacity to remember the inconsequential events of the day for any length of time is actually quite limited, although we are generally able to remember such events for a few hours. u. Frey prerequisite for event memory, factors contributing to the variable persistence of LTP could be of functional significance with respect to the strength or accessibility of memory 'traces'.

In this scenario, macromolecular synthesis is not expected to have a causal role in establishing the persistence of traces over time, but rather to have a role in supplying the synapse with resources for enhanced molecular turnover, in expanding synaptic space for future plasticity, and in homeostatic functions. Using a metaphor of the synapse as a motor vehicle, it has the engine required for a very long ride, but will evidently stop running in the absence of a continuous supply of fuel and spare parts.

However, the notion that consolidation is a function of the intensity of a single input might well be too simplistic. It is also not in accord with the natural situation, in which much of the information that we consolidate is distinguished from the nonconsolidated material by virtue of context and association rather than intensity. We therefore favor the notion that a time-dependent convergence of two or more events is required. Therefore, our second point is that the history of the neuron is important in the determination of stimulus intensity to induce late LTP (Frey and Morris 1997, 1998a, b).

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