Ciba Foundation Symposium 74 - Drug Concentrations in
Chapter 1 creation: The Rational Use of Plasma Drug degrees in scientific drugs (pages 1–12): Louis Lasagna
Chapter 2 rules of Pharmacokinetics (pages 13–33): Geoffrey T. Tucker
Chapter three Methodological Pitfalls: The impression of Experimental layout on effects (pages 35–49): Stephen H. Curry
Chapter four Interpretation of Drug degrees: Relevance of Plasma Protein Binding (pages 51–68): Emilio Perucca and Alan Richens
Chapter five quality controls of Drug Assays (pages 69–79): Alan Richens
Chapter 6 Lithium Concentrations and medical Responses (pages 81–98): John L. Crammer, A.C. Elithorn and R. Lennox
Chapter 7 Blood degrees of Flupenthixol in sufferers with Acute and protracted Schizophrenia (pages 99–114): Eve C. Johnstone, Rachel C. Bourne, P. Mary Cotes, T.J. Crow, I.N. Ferrier, F. Owen and J.D. Robinson
Chapter eight scientific importance of tracking Plasma degrees of Psychotropic medicines (pages 115–139): Paolo Lucio Morselli and Edouard Zarifian
Chapter nine Benzodiazepines: a few features in their medical Pharmacology (pages 141–155): Richard I. Shader and David J. Greenblatt
Chapter 10 Adrenergic and Serotonergic Mechanisms in melancholy and Their reaction to Amitriptyline (pages 157–166): Alec Coppen and Keith Wood
Chapter eleven The position of Plasma point tracking of Tricyclic Antidepressant medicines as an reduction to remedy (pages 167–197): Robin Braithwaite
Chapter 12 medical program of the tracking of Anticonvulsant Drug degrees (pages 199–214): E.H. Reynolds
Chapter thirteen The Logistics of Drug tracking (pages 215–224): Roy Goulding
Chapter 14 substitute techniques (pages 225–252): Malcolm Lader
Chapter 15 Concluding feedback (pages 253–255): Louis Lasagna
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Content material: bankruptcy 1 creation: The Rational Use of Plasma Drug degrees in medical drugs (pages 1–12): Louis LasagnaChapter 2 ideas of Pharmacokinetics (pages 13–33): Geoffrey T. TuckerChapter three Methodological Pitfalls: The impact of Experimental layout on effects (pages 35–49): Stephen H.
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Additional info for Ciba Foundation Symposium 74 - Drug Concentrations in Neuropsychiatry
We also compared the results from gas chromatography and mass fragmentography methods and found excellent agreement. When we tried to compare gas chromatography with radioimmunoassay, METHODOLOGICAL PITFALLS 45 however, there was no really good correlation, and we have been considering the reasons for that (cf. Larsen et a1 1979). I would suggest that at the outset we need to establish comparisons between laboratories so as to be able to control the results from the very beginning. My other general point is that I have learnt from my work with the drug regulatory agencies that the system of phases for drug evaluation (for details see World Health Organization 1975) is a good framework to have, and perhaps we should use such a system when we develop drug concentration monitoring.
Present address: College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Gainesville, Florida 32610, USA. H. CURRY PROBLEMS IN CHEMICAL ANALYSIS High quality chemical analysis preceded high quality clinical evaluation. However, controversies and errors in relation to assays are still found. The basic requirement in any analytical method is usually specific measurement of one known compound with reasonable precision and accuracy. I say usually, because there is a case for non-specific measurement in certain restricted situations, and this will be considered later.
It is also always important to bear in mind that, for some tricyclics and for some patients, quite a long time on a given daily dosage is required before the steady state is reached. This applies, for example, to clomipramine in which the principal metabolite, desmethylclomipramine, continues to build up in the plasma up to 6-8 weeks after initiation of treatment. The time required to reach steady-state plasma levels is therefore important. Pocock: I sit here as the tame statistician who is not terribly familiar with this area, but Dr Curry obviously wants to tempt me into saying a few nasty things and perhaps this is as good a time as any!