Treatment of Chronic Pain by Interventional Approaches: the by Timothy R Deer, Michael S Leong, Asokumar Buvanendran,

By Timothy R Deer, Michael S Leong, Asokumar Buvanendran, Vitaly Gordin, Philip S. Kim, Sunil J. Panchal, Albert L. Ray

From reports of Deer, eds., Comprehensive therapy of continual discomfort through scientific, Interventional, and Integrative Approaches:

"Comprehensive remedy of persistent soreness via clinical, Interventional, and Integrative techniques is a big textbook...
[I]t will be part of all departmental libraries and within the reference selection of soreness fellows and ache practitioners. in truth, this article may be to discomfort as Miller is to basic anesthesia.

Journal of Neurosurgical Anesthesiology

Edited by means of grasp clinician-experts appointed via the yank Academy of ache drugs, it is a gentle hide model of the Interventional sections of the acclaimed Deer, eds., Comprehensive remedy of persistent ache by means of clinical, Interventional, and Integrative Approaches. it really is meant as a first-rate reference for busy clinicians who search up to date and authoritative information regarding interventional ways to treating persistent pain.

  • State-of-the-art insurance of complete variety of innovations: neural blockades, neurolysis blocks, and neurostimulation
  • Review of clinically appropriate anatomy and physiology
  • "Key issues" preview contents of every chapter

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Extra info for Treatment of Chronic Pain by Interventional Approaches: the AMERICAN ACADEMY of PAIN MEDICINE Textbook on Patient Management

Sample text

Wolbers Key Points • Interventional techniques that target specific nociceptive transmission sites can reduce pain without having the systemic impact that oral medication have on other organ systems. • Convergence of nociceptive afferent signals in the spinal cord may explain the clinical observation that injury of different organs may produce the same pain sensations. • Destruction of specific spinal neural targets with either neurolytic solutions or thermal probes provides longterm relief for a limited number of pain conditions.

2009;12(6):965–83. 44. Verrills P, et al. Peripheral nerve field stimulation for chronic pain: 100 cases and review of the literature. Pain Med. 2011;3(10): 1526–4637. 1 Neuroanatomy and Neurophysiology of Pain 45. Mao J, et al. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci. 2002;22(17):7650–61. 46. Staats PS, et al. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial.

Production of nitric oxide (NO) increases via the Ca2+/calmodulindependent enzyme NO synthase. NO may diffuse out of the neuron to have a retrograde action on primary afferents and also activates guanylyl cyclase, leading to increases in intracellular cyclic guanosine monophosphate (cGMP) and activation of cGMP-dependent protein kinases. Activation of the Ca2+-dependent protein kinase C γ isoform (PKCγ) leads to phosphorylation of the NMDA receptor, which reduces the Mg2+ block (dotted line II) relating to the development of opioid tolerance.

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