Extracellular Potentials in the Hippocampus: Sources and by Antonio Fernández Ruiz

By Antonio Fernández Ruiz

In this thesis, the writer investigates the biophysical foundation of the neighborhood box capability (LFP) as a fashion of gaining a greater realizing of its underlying physiological mechanisms. the consequences characterize significant advances in our knowing and interpretation of LFPs and mind oscillations. They spotlight the significance of utilizing appropriate experimental and analytical how to discover the job of mind circuits and aspect to the LFP as an invaluable, yet complicated variable for this purpose.

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Extracellular Potentials in the Hippocampus: Sources and Biophysical Mechanisms

During this thesis, the writer investigates the biophysical foundation of the neighborhood box strength (LFP) as a manner of gaining a greater knowing of its underlying physiological mechanisms. the implications characterize significant advances in our knowing and interpretation of LFPs and mind oscillations. They spotlight the significance of utilizing appropriate experimental and analytical easy methods to discover the task of mind circuits and aspect to the LFP as an invaluable, yet advanced variable for this function.

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Nat Rev Neurosci 14:770–785 20. Fernández-Ruiz A, Herreras O (2013) Identifying the synaptic origin of ongoing neuronal oscillations through spatial discrimination of electric fields. Front Comput Neurosci 7:5 21. Fernández-Ruiz A, Makarov VA, Benito N, Herreras O (2012) Schaffer-specific local field potentials reflect discrete excitatory events at gamma frequency that may fire postsynaptic hippocampal CA1 units. J Neurosci 32:5165–5176 22. Fernández-Ruiz A, Makarov VA, Herreras O (2012) Sustained increase of spontaneous input and spike transfer in the CA3-CA1 pathway following long-term potentiation in vivo.

G. interneurons or glia). Most types of interneuros and astrocites have multipolar dendritic trees [1] and hence, a ‘closed-field’ extracellular configuration of the electric field is established by their synaptic activation (Lorente de Nó, 1947). Consequently, their currents do not (or they only poorly) spread beyond their physical limits [10, 19, 28]. In consequence, these cells do not significantly add their currents in the extracellular space and they only negligibly contribute to the LFP (even if they are strongly synchronized).

Vffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi u u Cxy ðf Þ 2 t cohxy ð f Þ ¼ jhCxx ðf Þij Á Cyy ðf Þ ð2:17Þ where Cxx(f) is the cross-spectral density for the frequency f between x and y, and h. i indicates averaging over segments. 3 Time-Frequency Analysis of LFPs 25 To assess spectral events at a high resolution in time and frequency, the complex wavelet transform (CWT) of the LFP was calculated using complex Morlet wavelets [42]. The CWT gives amplitude and phase measures for each wavelet scale at all time points in the data, obtained by convolving the real and imaginary parts (which are phase shifted by 90°) of the wavelets with the data vectors.

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